Installed Kstars on my Win 10 laptop. Connected, EQ6 and Canon 60D via USB cable. Both working OK using eqascom and EOS utility.
Now, I start Kstars and EKOS, next trying to connect INDI. It fails with the below error :

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Error

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Connection to INDI server at host localhost with port 7624 failed.

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&OK

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I tested it with profile simulator and also tried created new profile. I referred this: indilib.org/about/clients.html and now I am doubtful if EKOS is even supported on Win10 or it can run only with the VM.

You have INDI server running where exactly? You need an INDI server. If your devices have ASCOM drivers, then you can use INDI Server for Windows . On the other hand, you can get a raspberry pi and install INDI on it.