Should work fine. Right now one driver controls multiple cameras. Recently, I added a feature so that you can run one-camera per driver since it appears that using a single executable to manage multiple cameras might not work so well after all despite what the SDK claims. This feature was added to ZWO cameras, and will most likely be extended to QHY cameras once it is proven worthwhile.
I'm using QHY163 and old QHY5 (first version) on a single INDI driver and they work (mostly). Unfortunately this setup doesn't work on RaspberryPi 3 or 4. I only managed to get it working on intel based laptop. Please note I didn't yet try to use both cameras at the same time. I can only confirm that I can connect to both from KStars and take a single frame from each.
I suspect USB driver in RPi kernel. It might be more than that. Firstly with QHY163 camera it won't work with USB3 controller on RPi4. I didn't debug that so I don't know what the issue might be. If I force it to use USB2 mode (by either plugging to USB2 socket or using USB2 hub) I'm able to connect to the camera. It doesn't work always though. I noticed that I'm getting the best result if I connect to the camera while there is no power supply connected to it. This prevents the camera from cooling, but I can connect the power after I connect from RPi with INDI. Then I'm able to take a single frame and on the next attempt some error happens. I tried upgrading to the latest and greatest version of INDI and driver, but this just changed the error message I got. In the end I gave up with RPi4 and went with my laptop and powered USB2 hub. This setup works pretty consistently. I guess the next step will be replacing RPi4 with some cheap intel NUC so I don't have to carry the laptop to the mount.