I believe SkySafari can connect to an INDI server as another INDI Client.
INDI/KStars on Raspberry Pi 4, 4gb
Raspbian Buster with AstroPi3 script configuration
Skywatcher HEQ5 Pro Mount
Canon 600D Camera
Orion SSAG/ASI120mm @280mm Guide Scope
Adafruit Motor Hat shield
Adafruit GPS Module
Generic Bluetooth Joystick.
Startech 7 port powered USB Hub.
Yes it is possible. Select SkySafari as auxiliary driver and select LX200 in SkySafari. When starting Ekos you need to note the ip address and port for the SkySafari driver and make sure that SkySafari uses those to connect to INDI. No additional hardware needed.
ASI6200 and filter wheel with a SkyWatcher Esprit 80 ED on a SkyWatcher HEQ5-Pro
ASI1600MM-Pro Cooled and filter wheel with an 8" TS Ritchey-Chrétien on a SkyWatcher EQ6-R