It is possible but requires external hardware add's to the SE mount.
The caveat is that the scope needs to be perm mounted or can be placed in roughly the same spot if not.
In video linked below:
HC has external servo motors added controlled by an ESP32 webpage, the ESP uses the servo's to push the buttons on the HC to simply do a one star north align at whatever time was last stored in the HC and whatever star was chosen by the HC.
Then mounted on the SE are position sensors wired into a PI GPIO. INDI is launched and a script is run which uses SET PROP to first move the ALT axis to the sensor, reading the axis sensor output, followed by the AZ axis to it's sensor.
Now here is where the perm mounted or same physical mount position comes into play.
The pointing of the scope when positioned at the sensors will always be in the same spot in the sky, this position needs to be determined by a plate solve. Then given we know the sky position at the current local sidereral time, the next time the scope is started we know the DEC and the RA can be calculated by using the current LST and offsetting from the platesolved initial calibration.
Using INDI SETPROP the scope is forced SYN'ed to the DEC, RA and then the current time must be forced set into the HC.
This last step of setting Nexstar time -after- it was aligned is controversial, the INDI driver as written will not allow time to be set once aligned, I needed to modify the driver to allow it to happen. Since the HC is never used for GOTO's, etc and the scope is under computer control at all times, it works perfectly.
A demo video I did of all the above:
Gene