I think that I found the issue. It was not Ubuntu 22, it was my usb connection to my zwo asi 1600 was resetting, and that was causing general system slowness / lockup issues.

The dmsg log had many of these in it: "reset SuperSpeed USB device number 5 using xhci_hcd"



I installed Ubuntu 20 and it had the same issue. On further inspection I found that I needed to apply this setting in the bios to get past it:

USB Precondition: enabled
xHCI Mode: smart auto
trunk gating: enabled
per port disable control: enabled

The one that seemed to do the trick is "xHCI Mode: smart auto"

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