Indeed. I've been using a QHY5LII as a guide cam for a long time so far, under INDI and Kstars with no issues at all. Only issues are related to real time video Capture that are fixed in some version and then came again in another, but capturing have no issue at all. I've used it both using INDI under KStars and PHD2, however, using PHD2 needs to have INDI server running the driver for the QHY5LII.
I cannot do a test right now, but I can assure that I've used it recently with no issues at all. I'll do some tests with latest Astroberry version to be sure, however.