A datapoint on the other side. I have ASI imaging cam and also ASI guide cam running on Pi4 through powered USB hub using the standard INDI asi driver(s). I've never experienced any issues like those described. Not sure what to attribute this to, but I guess I'll thanks some lucky stars. Could it be that using a powered USB hub and reducing Pi's USB to just the hub data cable might help to eliminate these types of issues? It's something to think about.