With any given filter when the main imaging camera is focused correctly, is the guide camera also focused, or is it sometimes out of focus with some of your filters?
I use one of these on my OAG www.firstlightoptics.com/zwo-accessories...helical-focuser.html
It helps me easily adjust the focus.
I set it so that guide camera is completely in focus when we're using a filter that has an offset that's nearest the average of all the filters.