The host-OS on the laptop is Windows 10 and I also upgraded the VirtualBox to the latest version.
The QHY5-ii works under Windows 10 with the EZPlanetary program and the QHY5-ii can be assigned to the VM. it is possible to connect the camera in the INDI control Panel, but during the readout of the picture it stalls. The camera is initialized as the red LED is blinking and the blinking frequency corresponds somehow with the duration.
I cannot really verify if it ever worked before, because the QHYCCD did not work correctly in the navtive environment I tried in the past.

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