I logged debug info for the iOptronV3 driver and this is the error. I am not sure how to debug multiple INDI drivers at the same time, as I am not sure what happens first, the ASI CCD failing to expose, or the CEM40 not returning to the command. I will debug the ASI driver next.

T22:02:59.795 PDT DEBG ][ org.kde.kstars.indi] - Image received. Mode: "Guide" Size: 1237440
[2022-09-07T22:03:01.151 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[SCOPE] RES <+2073037511691336011> "
[2022-09-07T22:03:01.181 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] CMD <:GLS#> "
[2022-09-07T22:03:01.182 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] RES <-4432800050135700210931> "
[2022-09-07T22:03:01.182 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[SCOPE] CMD <:GEP#> "
[2022-09-07T22:03:01.182 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[SCOPE] RES <+2073037511691342011> "
[2022-09-07T22:03:01.182 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] CMD <:ZE00080#> "
[2022-09-07T22:03:01.852 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] CMD <:GLS#> "
[2022-09-07T22:03:01.876 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] RES <-4432800050135700210931> "
[2022-09-07T22:03:01.877 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[SCOPE] CMD <:GEP#> "
[2022-09-07T22:03:04.831 PDT INFO ][ org.kde.kstars.indi] - ZWO CCD ASI120MM Mini : "[ERROR] Exposure failed after 3 attempts. "
[2022-09-07T22:03:04.831 PDT INFO ][ org.kde.kstars.ekos.guide] - "Exposure failed. Restarting exposure..."
[2022-09-07T22:03:06.879 PDT INFO ][ org.kde.kstars.indi] - iOptronV3 : "[ERROR] Read Command Error: Timeout error "
[2022-09-07T22:03:07.479 PDT DEBG ][ org.kde.kstars.ekos.mount] - Mount status changed from "Tracking" to "Error"
[2022-09-07T22:03:07.882 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] CMD <:GLS#> "
[2022-09-07T22:03:08.446 PDT INFO ][ org.kde.kstars.indi] - ZWO CCD ASI120MM Mini : "[ERROR] Exposure failed after 3 attempts. "
[2022-09-07T22:03:08.446 PDT INFO ][ org.kde.kstars.ekos.guide] - "Exposure failed. Restarting exposure..."
[2022-09-07T22:03:11.459 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] RES <> "
[2022-09-07T22:03:11.466 PDT INFO ][ org.kde.kstars.indi] - iOptronV3 : "[ERROR] bool IOPv3::Driver::getStatus(IOPv3::IOPInfo*): Expected 23 bytes but received 0. "
[2022-09-07T22:03:11.467 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[SCOPE] CMD <:GEP#> "
[2022-09-07T22:03:11.482 PDT INFO ][ org.kde.kstars.indi] - iOptronV3 : "[ERROR] Write Command Error: Write Error: Input/output error "
[2022-09-07T22:03:12.067 PDT INFO ][ org.kde.kstars.indi] - ZWO CCD ASI120MM Mini : "[ERROR] Exposure failed after 3 attempts. "
[2022-09-07T22:03:12.067 PDT INFO ][ org.kde.kstars.ekos.guide] - "Exposure failed. Restarting exposure..."
[2022-09-07T22:03:12.457 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] CMD <:GLS#> "
[2022-09-07T22:03:12.459 PDT INFO ][ org.kde.kstars.indi] - iOptronV3 : "[ERROR] Write Command Error: Write Error: Input/output error "
[2022-09-07T22:03:12.459 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[SCOPE] CMD <:GEP#> "
[2022-09-07T22:03:12.461 PDT INFO ][ org.kde.kstars.indi] - iOptronV3 : "[ERROR] Write Command Error: Write Error: Input/output error "
[2022-09-07T22:03:13.458 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] CMD <:GLS#> "
[2022-09-07T22:03:13.460 PDT INFO ][ org.kde.kstars.indi] - iOptronV3 : "[ERROR] Write Command Error: Write Error: Input/output error "

The only part that is weird is this : [2022-09-07T22:03:01.182 PDT DEBG ][ org.kde.kstars.indi] - iOptronV3 : "[DEBUG] CMD <:ZE00080#> "

The driver has this as a guide command, but I can't find it in the RS-232 command set, that instead appears to be expecting motion commands to be prefixed with :M

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