I have a similar setup:
- Astroberry running on Pi
- NexStar 8 SE from hand controller to Pi to USB 2.0 port, (serial connection)
- ZWO (or QHY) camera plugged into USB 3.0 port
- JMI focuser USB controller plugged into USB 2.0 port
- No Celestron focuser or Star Sense (Star Sense is not needed as INDI EKOS has plate-solving module)

I would recommend trying connecting one component at a time starting with mount and seeing how that works out.