I run 3 rigs now using this board. Pretty much all of them are using:
1. OnStep mount controllers which also drives focuser
2. ASI174 or ASI120 guide camera
3. Touptek IMX571 mono camera
4. SX Filter Wheel
Touptek camera has an internal hub, which I am using for running filter wheel and guider.
I don't need to use a separate USB hub and I even have a spare USB port.
I encountered couple of issues:
1. Once in a while I had issues with running main camera using USB3 port, so I normally use USB2 port for camera.
2. There was a weird issue where one of the rigs was not able to connect to the main camera. It turned out that a DC/DC converter from 12v to 5v was at fault. No idea why, because rest of the things were working just fine. Maybe it was not strong enough or had poor signal. Once I replaced it, all is working fine.
So some suggestions are:
1. Use separate power supplies for powering different components
2. Try using USB2 port for camera and also use USB2 cable
3. Try to get rid of USB hub, at least temporarily, I always had problems with USB hubs, especially 7 port ones
4. If you have issue with serial connection, you need to make your user as part of dialout group. You can find command in my Makefile
5. I also use tightvnc, see my script how it is installed

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